Reticular Erythematous Mucinosis (REM): Case Report and Review of Literature
Main Article Content
Keywords
Reticular Erythematous Mucinosis, REM, Lupus Tumidus, Mucinosis, Cutaneous lupus
Abstract
Reticular erythematous mucinosis (REM) is a rare disorder with an unknown etiology. REM requires both a clinical and a pathological diagnosis. Multiple relevant associations and triggers are known. Herein, we report a classic case of REM, whose condition was found to be correlated with smoking and exacerbated by sun exposure. Our diagnostic and treatment approach is based on a worldwide review of current research, and this report aims to demonstrate a classical presentation of REM and available treatment options that have proved efficacious to date.
References
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2. Meewes C, Henrich A, Krieg T, Hunzelmann N. Treatment of reticular erythematous mucinosis with UV-A1 radiation. Arch Dermatol. 2004 Jun;140(6):660-2. PubMed PMID: 15210454.
3. Braddock SW, Davis CS, Davis RB. Reticular erythematous mucinosis and thrombocytopenic purpura. Report of a case and review of the world literature, including plaquelike cutaneous mucinosis. J Am Acad Dermatol. 1988 Nov;19(5 Pt 1):859-68. Review. PubMed PMID: 3056996.
4. Steigleder GK, Gartmann H, Linker U. REM syndrome: reticular erythematous mucinosis (round-cell erythematosis), a new entity? Br J Dermatol. 1974 Aug;91(2):191-9. PubMed PMID: 4472292.
5. Rongioletti F, Merlo V, Riva S, Cozzani E, Cinotti E, Ghigliotti G, Parodi A, Kanitakis J. Reticular erythematous mucinosis: a review of patients' characteristics, associated conditions, therapy and outcome in 25 cases. Br J Dermatol. 2013 Dec;169(6):1207-11. doi: 10.1111/bjd.12577. PubMed PMID: 23937648.
6. Kucukunal A, Altunay I, Demirci GT, Sarikaya S, Sakiz D. Reticular erythematous mucinosis on the midline of the back. Cutis. 2014 Jun;93(6):294-6. PubMed PMID: 24999640.
7. Thareja S, Paghdal K, Lien MH, Fenske NA. Reticular erythematous mucinosis--a review. Int J Dermatol. 2012 Aug;51(8):903-9. doi: 10.1111/j.1365-4632.2011.05292.x. Review. PubMed PMID: 22788804.
8. Fernandez-Flores A, Saeb-Lima M. Mucin as a diagnostic clue in dermatopathology. J Cutan Pathol. 2016 Nov;43(11):1005-1016. doi: 10.1111/cup.12782. Review. PubMed PMID: 27500958.
9. Cinotti E, Merlo V, Kempf W, Carli C, Kanitakis J, Parodi A, Rongioletti F. Reticular erythematous mucinosis: histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus. J Eur Acad Dermatol Venereol. 2015 Apr;29(4):689-97. doi: 10.1111/jdv.12654. PubMed PMID: 25087914.
10. Haendchen LC, Sabbag DS, Furlani Wde J, de Souza PK, Rotta O. Reticular erythematous mucinosis. Cutis. 2014 Mar;93(3):E21-4. PubMed PMID: 24738106.
11. Adamski H, Le Gall F, Chevrant-Breton J. Positive photobiological investigation in reticular erythematous mucinosis syndrome. Photodermatol Photoimmunol Photomed. 2004 Oct;20(5):235-8. PubMed PMID: 15379872.
12. McFadden N, Larsen TE. Reticular erythematous mucinosis and photosensitivity: a case study. Photodermatol. 1988 Dec;5(6):270-2. PubMed PMID: 3249684.
13. Morison WL, Shea CR, Parrish JA. Reticular erythematous mucinosis syndrome. Report of two cases. Arch Dermatol. 1979 Nov;115(11):1340-2. PubMed PMID: 507890.
14. Miyoshi K, Miyajima O, Yokogawa M, Sano S. Favorable response of reticular erythematous mucinosis to ultraviolet B irradiation using a 308-nm excimer lamp. J Dermatol. 2010 Feb;37(2):163-6. doi: 10.1111/j.1346-8138.2009.00779.x. PubMed PMID: 20175851.
15. Lin Q, Luo DQ, Liu JH, Yang W. Hydroxychloroquine-induced reversible hypomnesis in a patient with reticular erythematous mucinosis. Ann Dermatol. 2012 Nov;24(4):490-1. doi: 10.5021/ad.2012.24.4.490. PubMed PMID: 23197926; PubMed Central PMCID: PMC3505791.
16. Susok L, Kreuter A. Complete clearance of reticular erythematous mucinosis with quinacrine monotherapy. Arch Dermatol. 2012 Jun;148(6):768-9. doi: 10.1001/archdermatol.2012.53. PubMed PMID: 22710470.
17. Mansouri P, Farshi S, Nahavandi A, Safaie-Naraghi Z. Pimecrolimus 1 percent cream and pulsed dye laser in treatment of a patient with reticular erythematous mucinosis syndrome. Dermatol Online J. 2007 May 1;13(2):22. PubMed PMID: 17498441.
18. Greve B, Raulin C. Treating REM syndrome with the pulsed dye laser. Lasers Surg Med. 2001;29(3):248-51. PubMed PMID: 11573227.
19. Yamazaki S, Katayama I, Kurumaji Y, Yokozeki H, Nishioka K. Treatment of reticular erythematous mucinosis with a large dose of ultraviolet B radiation and steroid impregnated tape. J Dermatol. 1999 Feb;26(2):115-8. PubMed PMID: 10091482.
20. Amherd-Hoekstra A, Kerl K, French LE, Hofbauer GF. Reticular Erythematous Mucinosis in an atypical pattern distribution responds to UVA1 phototherapy. J Eur Acad Dermatol Venereol. 2014 May;28(5):672-3. doi: 10.1111/jdv.12247. PubMed PMID: 23952909.
2. Meewes C, Henrich A, Krieg T, Hunzelmann N. Treatment of reticular erythematous mucinosis with UV-A1 radiation. Arch Dermatol. 2004 Jun;140(6):660-2. PubMed PMID: 15210454.
3. Braddock SW, Davis CS, Davis RB. Reticular erythematous mucinosis and thrombocytopenic purpura. Report of a case and review of the world literature, including plaquelike cutaneous mucinosis. J Am Acad Dermatol. 1988 Nov;19(5 Pt 1):859-68. Review. PubMed PMID: 3056996.
4. Steigleder GK, Gartmann H, Linker U. REM syndrome: reticular erythematous mucinosis (round-cell erythematosis), a new entity? Br J Dermatol. 1974 Aug;91(2):191-9. PubMed PMID: 4472292.
5. Rongioletti F, Merlo V, Riva S, Cozzani E, Cinotti E, Ghigliotti G, Parodi A, Kanitakis J. Reticular erythematous mucinosis: a review of patients' characteristics, associated conditions, therapy and outcome in 25 cases. Br J Dermatol. 2013 Dec;169(6):1207-11. doi: 10.1111/bjd.12577. PubMed PMID: 23937648.
6. Kucukunal A, Altunay I, Demirci GT, Sarikaya S, Sakiz D. Reticular erythematous mucinosis on the midline of the back. Cutis. 2014 Jun;93(6):294-6. PubMed PMID: 24999640.
7. Thareja S, Paghdal K, Lien MH, Fenske NA. Reticular erythematous mucinosis--a review. Int J Dermatol. 2012 Aug;51(8):903-9. doi: 10.1111/j.1365-4632.2011.05292.x. Review. PubMed PMID: 22788804.
8. Fernandez-Flores A, Saeb-Lima M. Mucin as a diagnostic clue in dermatopathology. J Cutan Pathol. 2016 Nov;43(11):1005-1016. doi: 10.1111/cup.12782. Review. PubMed PMID: 27500958.
9. Cinotti E, Merlo V, Kempf W, Carli C, Kanitakis J, Parodi A, Rongioletti F. Reticular erythematous mucinosis: histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus. J Eur Acad Dermatol Venereol. 2015 Apr;29(4):689-97. doi: 10.1111/jdv.12654. PubMed PMID: 25087914.
10. Haendchen LC, Sabbag DS, Furlani Wde J, de Souza PK, Rotta O. Reticular erythematous mucinosis. Cutis. 2014 Mar;93(3):E21-4. PubMed PMID: 24738106.
11. Adamski H, Le Gall F, Chevrant-Breton J. Positive photobiological investigation in reticular erythematous mucinosis syndrome. Photodermatol Photoimmunol Photomed. 2004 Oct;20(5):235-8. PubMed PMID: 15379872.
12. McFadden N, Larsen TE. Reticular erythematous mucinosis and photosensitivity: a case study. Photodermatol. 1988 Dec;5(6):270-2. PubMed PMID: 3249684.
13. Morison WL, Shea CR, Parrish JA. Reticular erythematous mucinosis syndrome. Report of two cases. Arch Dermatol. 1979 Nov;115(11):1340-2. PubMed PMID: 507890.
14. Miyoshi K, Miyajima O, Yokogawa M, Sano S. Favorable response of reticular erythematous mucinosis to ultraviolet B irradiation using a 308-nm excimer lamp. J Dermatol. 2010 Feb;37(2):163-6. doi: 10.1111/j.1346-8138.2009.00779.x. PubMed PMID: 20175851.
15. Lin Q, Luo DQ, Liu JH, Yang W. Hydroxychloroquine-induced reversible hypomnesis in a patient with reticular erythematous mucinosis. Ann Dermatol. 2012 Nov;24(4):490-1. doi: 10.5021/ad.2012.24.4.490. PubMed PMID: 23197926; PubMed Central PMCID: PMC3505791.
16. Susok L, Kreuter A. Complete clearance of reticular erythematous mucinosis with quinacrine monotherapy. Arch Dermatol. 2012 Jun;148(6):768-9. doi: 10.1001/archdermatol.2012.53. PubMed PMID: 22710470.
17. Mansouri P, Farshi S, Nahavandi A, Safaie-Naraghi Z. Pimecrolimus 1 percent cream and pulsed dye laser in treatment of a patient with reticular erythematous mucinosis syndrome. Dermatol Online J. 2007 May 1;13(2):22. PubMed PMID: 17498441.
18. Greve B, Raulin C. Treating REM syndrome with the pulsed dye laser. Lasers Surg Med. 2001;29(3):248-51. PubMed PMID: 11573227.
19. Yamazaki S, Katayama I, Kurumaji Y, Yokozeki H, Nishioka K. Treatment of reticular erythematous mucinosis with a large dose of ultraviolet B radiation and steroid impregnated tape. J Dermatol. 1999 Feb;26(2):115-8. PubMed PMID: 10091482.
20. Amherd-Hoekstra A, Kerl K, French LE, Hofbauer GF. Reticular Erythematous Mucinosis in an atypical pattern distribution responds to UVA1 phototherapy. J Eur Acad Dermatol Venereol. 2014 May;28(5):672-3. doi: 10.1111/jdv.12247. PubMed PMID: 23952909.
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Published
Nov 9, 2018
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How to Cite
Rajaii, R., Moon, S., Nyckowski, T., Pui, J., & Mahon, M. (2018). Reticular Erythematous Mucinosis (REM): Case Report and Review of Literature. SKIN The Journal of Cutaneous Medicine, 2(6). https://doi.org/10.25251/skin.2.6.11
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