Successful Treatment of Granuloma Annulare with Certolizumab
Generalized granuloma annulare (GA) is a subtype of GA that consists of widespread annular papules and plaques varying in size. There are no randomized trials of treatment for GA, however topical treatment, phototherapy, and various systemic therapies, have been reported to be effective. We report the first case of generalized GA that is successfully treated with certolizumab pegol.
Brodell RT, Stratman, Erik, Ofori O, Abena. Granuloma annulare UpToDate: UpToDate; 2019 [updated June 18, 2019. Available from: https://www.uptodate.com/contents/granuloma-annulare.
American Academy of Dermatology Association. GRANULOMA ANNULARE : OVERVIEW 2019 [Available from: https://www.aad.org/public/diseases/rashes/granuloma-annulare.
National Center for Advancing Translational Sciences. Granuloma Annulare 2019 [updated August 02, 2018. Available from: https://rarediseases.info.nih.gov/diseases/6546/granuloma-annulare.
Schmieder SJ, Schmieder GJ. Granuloma Annulare. StatPearls. Treasure Island (FL)2019.
Goel N, Stephens S. Certolizumab Pegol. MAbs. 2010;2(2):137-47.
Chen A, Truong AK, Worswick S. The role of biologics in the treatment of chronic granuloma annulare. Int J Dermatol. 2019;58(5):622-26
Bürgler C, Vinay K, Häfliger S, Klötgen HW, Yawalkar N. Infliximab reduces activated myeloid dendritic cells, different macrophage subsets and CXCR3‐positive cells in granuloma annulare. 2019; J Dermatol(epub).
Min MS, Lebwohl M. Treatment of recalcitrant granuloma annulare (GA) with adalimumab: a single‐center, observational study. J Am Acad Dermatol. 2016 Jan;74(1):127-33.
Cessak G, Kuzawinska O, Burda A, Lis K, Wojnar M, Mirowska-Guzel D, et al. TNF inhibitors - Mechanisms of action, approved and off-label indications. Pharmacol Rep. 2014;66(5):836-44.
Schreiber S. Certolizumab pegol for the treatment of Crohn's disease. Therap Adv Gastroenterol. 2011;4(6):375-89.
Abstract - 117 PDF - 64
- There are currently no refbacks.