Nab-paclitaxel/Gemcitabine Induced Acquired Ichthyosis

Main Article Content

Adriana T Lopez
Joel Shugar
Mark Lebwohl

Keywords

acquired ichthyosis, ichthyoses, gemcitabine, nab-paclitaxel

Abstract

The ichthyoses are a diverse group of cutaneous disorders characterized by abnormalities in cornification. The majority of ichthyoses are inherited with childhood presentation and new onset ichthyosis in adulthood warrants further medical evaluation. Though most well recognized for its association with Hodgkin’s disease, acquired ichthyosis (AI) has been linked to a number of inflammatory, autoimmune, and endocrine processes. However, drug induced AI is exceedingly rare and remains a poorly understood entity. Here we report the case of man with who developed AI while receiving nab-paclitaxel plus gemcitabine for treatment of pancreatic adenocarcinoma and review the literature.

References

1. Kim BE, Howell MD, Guttman-Yassky E, et al. TNF-alpha downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-alpha antagonists to improve skin barrier. J Invest Dermatol. 2011;131(6):1272-1279.

2. Patel N, Spencer LA, English JC, III, Zirwas MJ. Acquired ichthyosis. Journal of the American Academy of Dermatology. 2006;55(4):647-656.

3. London RD, Lebwohl M. Acquired ichthyosis and hyperparathyroidism. Journal of the American Academy of Dermatology. 1989;21(4 Pt 1):801-802.

4. DYKES PJ, MARKS R. Acquired ichthyosis: multiple causes for an acquired generalized disturbance in desquamation. British Journal of Dermatology. 1977;97(3):327-334.

5. Yokote R, Iwatsuki K, Hashizume H, Takigawa M. Lymphomatoid papulosis associated with acquired ichthyosis. Journal of the American Academy of Dermatology. 1994;30(5):889-892.

6. Aram H. Acquired ichthyosis and related conditions. Int J Dermatol. 1984;23(7):458-461.

7. Chiewchanvit S, Noppakun K, Kanchanarattanakorn K. Mucocutaneous complications of chemotherapy in 74 patients from Maharaj Nakorn Chiang Mai Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2004;87(5):508-514.

8. Alloo A, Sheu J, Butrynski JE, et al. Ponatinib‐induced pityriasiform, folliculocentric and ichthyosiform cutaneous toxicities. British Journal of Dermatology. 2015;173(2):574-577.

9. Mittal A, Leventhal JS. Gemcitabine-associated acute lipodermatosclerosislike eruption: An underrecognized phenomenon. JAAD Case Reports. 2017;3(3):190-195.

10. Curtis S, Hong S, Gucalp R, Calvo M. Gemcitabine-Induced Pseudocellulitis in a Patient With Recurrent Lymphedema: A Case Report and Review of the Current Literature. American journal of therapeutics. 2016;23(1):e321-323.

11. Bogdan C, Ding A. Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages. J Leukoc Biol. 1992;52(1):119-121.

12. Dima SO, Tanase C, Albulescu R, et al. An exploratory study of inflammatory cytokines as prognostic biomarkers in patients with ductal pancreatic adenocarcinoma. Pancreas. 2012;41(7):1001-1007.

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>