Successful Dupilumab Treatment of Atopic Dermatitis in a Liver Transplant Patient

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Amanda Krenitsky
Sairekha Ravichandran
Joel Cohen
Jonathan Braue
Lilia Correa-Selm

Keywords

Transplant, Dupixent, Dupilumab, Atopic Dermatitis, scaly, AD

Abstract

Atopic dermatitis (AD) in liver transplant (LT) recipients is well-documented, despite frequent use of immunosuppressants in these patients. In a liver transplant population, the prevalence of AD in children and adults is 27.6% and 10.3%, respectively.1 However, there is dearth ofliterature regardingtreatment of this population, and standard regimens are not well-defined.2-4 Here, we report a case of successful treatment of AD in an orthotopic LT patient with dupilumab. 

References

1. Topal E, Çatal F, Selimoğlu MA, et al. Acquired atopic disease after liver transplantation in children; similarities to and differences from adults: a preliminary study. Eur J Gastroenterol Hepatol. Sep 2014;26(9):1055-9. doi:10.1097/meg.0000000000000142

2. Ludriksone L, Elsner P, Malessa C, Settmacher U, Schliemann S. Effectiveness and safety of dupilumab for atopic dermatitis in a liver transplant recipient: a case report. J Dtsch Dermatol Ges. Jul 2020;18(7):740-742. doi:10.1111/ddg.14074

3. Kha C, Raji K, Chisolm S. Treatment of Atopic Dermatitis With Dupilumab in a Renal Transplant Patient. Dermatitis. Mar/Apr 2020;31(2):e17-e18. doi:10.1097/der.0000000000000560

4. Jamgochian M, Milgraum D, Milgraum S, Pappert A. Dupilumab as treatment for atopic dermatitis in a pediatric heart transplant patient: A case report. Dermatol Ther. Nov 2020;33(6):e14018. doi:10.1111/dth.14018

5. Tsianakas A, Ständer S. Dupilumab: a milestone in the treatment of atopic dermatitis. Lancet. Jan 2 2016;387(10013):4-5. doi:10.1016/s0140-6736(15)00389-x

6. Product Approval Information - Licensing Action Dupixent (dupilumab). Available online at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/761055lbl.pdf (accessed on 06 Sep 2021).

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