A Case of Kaposi Sarcoma Co-infected with Cytomegalovirus
Background: Kaposi sarcoma (KS) is the most common AIDS-associated neoplasm. It is a vascular neoplasm that occurs as a result of infection with a human herpesvirus (HHV-8). Cytomegalovirus (CMV) and HHV-8 both belong to Herpesviridae, a family of DNA viruses. CMV is highly prevalent in the general population and can cause localized or disseminated disease in AIDS patients.
Case: A 42-year-old male with an HIV infection presented with a painful ulcerated growing white nodule with overlying telangiectatic vessels on the right third toe that he noticed 4 weeks ago. A tangential biopsy revealed a vascular proliferation which was diffusely positive for HHV-8. In addition, scattered inclusion bodies were observed, indicating co-infection with CMV.
Conclusion: This case reinforces the importance of considering KS as a potential diagnosis in all AIDS patients with unusual exophytic growths to avoid potential misdiagnosis and improper management.
Schneider, J.W. and D.P. Dittmer, Diagnosis and Treatment of Kaposi Sarcoma. Am J Clin Dermatol, 2017. 18(4): p. 529-539.
Colugnati, F.A., et al., Incidence of cytomegalovirus infection among the general population and pregnant women in the United States. BMC Infect Dis, 2007. 7: p. 71.
Thakker, S. and S.C. Verma, Co-infections and Pathogenesis of KSHV-Associated Malignancies. Front Microbiol, 2016. 7: p. 151.
Vieira, J., et al., Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirus. J Virol, 2001. 75(3): p. 1378-86.
Crum-Cianflone, N.F., et al., Is Kaposi's sarcoma occurring at higher CD4 cell counts over the course of the HIV epidemic? AIDS, 2010. 24(18): p. 2881-3.
Zhang, X., et al., Simultaneous cytomegalovirus infection and Kaposi's sarcoma of the thyroid diagnosed by fine needle aspiration in an AIDS patient. A case report and first cytologic description of the two entities occurring together. Acta Cytol, 2003. 47(4): p. 645-8.
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