Low Rate of Keloid Recurrences Following Treatment of Keloidectomy Sites with a Biologically Effective Dose 30 of Superficial Radiation

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Brian Berman MD, PhD
Mark S. Nestor, MD, PhD
Michael H. Gold, MD
David J. Goldberg, JD, MD
Joshua Fox
George Schmieder, DO


Keloid, SRT, Superfical Radiation Therapy, keloidectomy, Recurerrence


Recurrences of keloids at sites of previously excised keloids is a well-recognized common occurrence following keloidectomy, and based on the published literature, has been reported to occur approximately in 71% of cases (1).  Superficial radiation reduces wound fibroblast proliferation and enhances apoptosis (2).  In this multi-center, case series report the recurrence rate of keloids post keloidectomy with peri-operative treatment with a biological effective dose 30 of superficial radiation (3) was determined to be 3.0%


1. Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG et al. International Advisory Panel on Scar Management. International clinical recommendations on scar management. Plast Reconstr Surg 2002; 110: 560–571

2. Liu X1, Liu JZ, Zhang E, Li P, Zhou P, Cheng TM, Zhou YG. Impaired wound healing after local soft x-ray irradiation in rat skin: time course study of pathology, proliferation, cell cycle, and apoptosis. J Trauma. 2005 Sep;59(3):682-90.

3. Kal HB and Veen RE. Biologically Effective Doses of Postoperative Radiotherapy in the Prevention of Keloids. Dose-Effect Relationship. Strahlentherapie und Onkologie November 2005, Volume 181, Issue 11, pp 717–7

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