Low Rate of Keloid Recurrences Following Treatment of Keloidectomy Sites with a Biologically Effective Dose 30 of Superficial Radiation
Recurrences of keloids at sites of previously excised keloids is a well-recognized common occurrence following keloidectomy, and based on the published literature, has been reported to occur approximately in 71% of cases (1). Superficial radiation reduces wound fibroblast proliferation and enhances apoptosis (2). In this multi-center, case series report the recurrence rate of keloids post keloidectomy with peri-operative treatment with a biological effective dose 30 of superficial radiation (3) was determined to be 3.0%
Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG et al. International Advisory Panel on Scar Management. International clinical recommendations on scar management. Plast Reconstr Surg 2002; 110: 560–571
Liu X1, Liu JZ, Zhang E, Li P, Zhou P, Cheng TM, Zhou YG. Impaired wound healing after local soft x-ray irradiation in rat skin: time course study of pathology, proliferation, cell cycle, and apoptosis. J Trauma. 2005 Sep;59(3):682-90.
Kal HB and Veen RE. Biologically Effective Doses of Postoperative Radiotherapy in the Prevention of Keloids. Dose-Effect Relationship. Strahlentherapie und Onkologie November 2005, Volume 181, Issue 11, pp 717–7
Abstract - 444 Full Article PDF - 195
- There are currently no refbacks.