Relapsing Polychondritis Masquerading as Auricular Pseudolymphoma: Case Report and Literature Review

Main Article Content

Faraz Yousefian, DO
Goodman Dermatology, Roswell, GA.
https://orcid.org/0000-0001-7032-7795
Mary Michael, DO
Larkin Community Hospital Palm Springs Campus Dermatology, Palm Springs, Florida.

Sujitha Yadlapati, MD
HCA Corpus Christi Medical Center-Bay Area Dermatology Residency Program, McAllen, TX.

Emily Sedaghat, MD
HCA Florida Kendall Hospital, Miami, Florida

Brad Glick, DO, MPH, FAAD
Larkin Community Hospital Palm Springs Campus Dermatology, Palm Springs, Florida.

Keywords

Relapsing Polychondritis

Abstract

Relapsing Polychondritis (RP) is a rare autoimmune disease associated with recurring inflammatory episodes predominantly affecting cartilage and other tissues throughout the body, including proteoglycan-rich structures. It is characterized by gradual deformation of tissue that leads to impairment of normal function. Areas involved include, but are not limited to, the respiratory tract, eyes, nose, joints, and vascular system. The inflammation targets cartilage, most commonly causing auricular and nasal chondritis but can involve cartilage throughout the body. Diagnosis of RP is often hindered by the vast variety of symptoms associated with this systemic disease and subtle symptomatology. In this paper, we demonstrate a case of relapsing polychondritis masquerading as pseudolymphoma and review recent literature relating to pathogenesis, diagnosis and treatment.

References

1. Vitale A, Sota J, Rigante D, et al. Relapsing Polychondritis: an Update on Pathogenesis, Clinical Features, Diagnostic Tools, and Therapeutic Perspectives. Curr Rheumatol Rep. 2016;18(1):3.

2. Letko E, Zafirakis P, Baltatzis S, Voudouri A, Livir-Rallatos C, Foster CS. Relapsing polychondritis: a clinical review. Semin Arthritis Rheum. 2002;31(6):384-395.

3. Relapsing polychondritis - about the disease - genetic and rare diseases information center. Accessed March 16, 2023. https://rarediseases.info.nih.gov/diseases/7417/relapsing-polychondritis

4. Molina JF, Espinoza LR. Relapsing polychondritis. Baillieres Best Pract Res Clin Rheumatol. 2000;14(1):97-109.

5. Borgia F, Giuffrida R, Guarneri F, Cannavò SP. Relapsing Polychondritis: An Updated Review. Biomedicines. 2018;6(3). doi:10.3390/biomedicines6030084

6. Ernst A, Rafeq S, Boiselle P, et al. Relapsing polychondritis and airway involvement. Chest. 2009;135(4):1024-1030.

7. Kingdon J, Roscamp J, Sangle S, D’Cruz D. Relapsing polychondritis: a clinical review for rheumatologists. Rheumatology . 2018;57(9):1525-1532.

8. Bachor E, Blevins NH, Karmody C, Kühnel T. Otologic manifestations of relapsing polychondritis. Review of literature and report of nine cases. Auris Nasus Larynx. 2006;33(2):135-141.

9. Schumacher S, Pieringer H. Relapsing polychondritis: a chameleon among orphan diseases. Wien Med Wochenschr. 2017;167(9-10):227-233.

10. UpToDate. Accessed March 16, 2023. https://www.uptodate.com/contents/clinical-manifestations-of-relapsing-polychondritis

11. Cantarini L, Vitale A, Brizi MG, et al. Diagnosis and classification of relapsing polychondritis. J Autoimmun. 2014;48-49:53-59.

12. Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W. Relapsing polychondritis: state-of-the-art review with three case presentations. Postgrad Med. 2021;133(8):953-963.

13. Smylie A, Malhotra N, Brassard A. Relapsing Polychondritis: A Review and Guide for the Dermatologist. Am J Clin Dermatol. 2017;18(1):77-86.

14. Puéchal X, Terrier B, Mouthon L, Costedoat-Chalumeau N, Guillevin L, Le Jeunne C. Relapsing polychondritis. Joint Bone Spine. 2014;81(2):118-124.

15. Yanagi T, Matsumura T, Kamekura R, Sasaki N, Hashino S. Relapsing polychondritis and malignant lymphoma: is polychondritis paraneoplastic? Arch Dermatol. 2007;143(1):89-90.

Article Sidebar

PDF
Published
Jul 23, 2024
DOI https://doi.org/10.25251/skin.8.4.16

Article Details

How to Cite
Yousefian, F., Michael, M., Yadlapati, S., Sedaghat, E., & Glick, B. (2024). Relapsing Polychondritis Masquerading as Auricular Pseudolymphoma: Case Report and Literature Review. SKIN The Journal of Cutaneous Medicine, 8(4), 1732–1736. https://doi.org/10.25251/skin.8.4.16
Issue
Vol. 8 No. 4 (2024): July 2024 Issue
Section
Brief Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All authors retain copyright in their articles. All articles published open access allowing for immediate free access to the work and permitting any user to read, download, copy, distribute, print, search, or link to the full texts of articles, crawl them for indexing, pass them as data to software or use them for any other lawful purpose. Permitted reuse is defined by  the following user license:
 

Creative Commons Attribution (CC BY): lets others distribute and copy the article, to create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, even for commercial purposes, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, and do not modify the article in such a way as to damage the author's honor or reputation. 

Authors retain copyright in their work and license the publisher to publish the content. The publisher is the National Society for Cutaneous Medicine, with production and publishing support provided by OJS, Open Journal Systems,see https://pkp.sfu.ca/ojs/.

Prior to January 2022, authors transferred copyright to the National Society for Cutaneous Medicine. However, all articles are freely available to anyone in the world. There are no subscription fees, page charges, or article processing charges.