Distinguishing Features: Staphylococcal Scalded Skin Syndrome vs Toxic Epidermal Necrolysis

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Staphylococcal scalded skin syndrome, toxic epidermal necrolysis, dermal-epidermal blister, sub-corneal blister


Staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) are dermatologic conditions that have a similar clinical appearance.  Careful attention to clinical features, such as the coloration at the base of the blister, and histopathology are utilized to make an accurate diagnosis.  While supportive therapy is required for both conditions, SSSS requires appropriate antibiotics to treat the underlying staphylococcus and TEN requires elimination of an offending drug (usually an antibiotic).  


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