Squamous Cell Carcinoma Arising in a Nevus Sebaceus in a 10-Year-Old Male

Main Article Content

Hannah Porter
Rebecca Lapides
Keith Morley
Laura Greene
Chin Ho


nevus sebaceous, pediatric nevus sebaceous, squamous cell carcinoma, squamous cell carcinoma within nevus sebaceous


The patient is a 10-year-old male who presented to a dermatologist regarding a bleeding plaque on the right scalp. The initial pathology report demonstrated an atypical endophytic squamous proliferation with an infiltrative pattern, raising concern for squamous cell carcinoma versus pseudoepitheliomatous hyperplasia. Physical exam showed a painless 4.4 x 1.2 cm elliptical, rough, orange-to-pink plaque with waxy superficial scale on the left forehead. Wide local excision was performed, and pathology confirmed no residual carcinoma. Squamous cell carcinoma arising in a nevus sebaceous in a pediatric patient is exceedingly rare, but as demonstrated by this case, does occur, emphasizing the need for improved guidelines for management to optimize treatment in the pediatric population.


1. Taher M, Feibleman C, Bennett R. Squamous Cell Carcinoma Arising in a Nevus Sebaceous of Jadassohn in a 9 Year Old Girl: Treatment using Mohs Micrographic Surgery with Literature Review. Dermatol Surg. 2010;36:1203-1208. [PMID: 20533930].

2. Belhadjali H, Moussa A, Yahia S et al. Simultaneous Occurrence of Two Squamous Cell Carcinomas Within A Nevus Sebaceous of Jadassohn in an 11 Year Old Girl. Pediatr Dermatol. 2009;26:236-237. [PMID: 19419489].

3. Achavanuntakul P, Thanomkitti K. Squamous Cell Carcinoma within a Congenital Nevus Sebaceous: Case Report and Literature Review. Case Rep Dermatol. 2021;13:75-82. [PMID: 33708087;].

4. Idriss MH, Elston DM. Secondary neoplasms associated with nevus sebaceus of Jadassohn: A study of 707 cases. J Am Acad Dermatol. 2014;70:332-337. [PMID: 24268309].

5. Locke ST, Schaffenburg WC, Breedlove JP, Davis Ii DW, Bowden Iii LP, Royer MC. Squamous cell carcinoma with perineural involvement in nevus sebaceus. Cutis. 2019;103:E17-E19. [PMID: 31116824].

6. Simi CM, Rajalakshmi T, Correa M. Clinicopathologic analysis of 21 cases of nevus sebaceus: a retrospective study. Indian J Dermatol Venereol Leprol. 2008;74:625-7. [PMID: 19171988].