Development of Multiple Facial Lipomas During Immunotherapy for Metastatic Squamous Cell Carcinoma

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Kathryn Hall
Adrian Guevara


immunotherapy, lipoma, Adipogenesis, Immune Checkpoint Inhibitors, PD-1 Inhibitor, Pembrolizumab, Tertiary Lymph Structure


An 85-year-old Caucasian male on immunotherapy for metastatic squamous cell carcinoma presented with enlarging lipomas in the area of his previous invasive squamous cell carcinoma of the lower lip and chin, status post resection, reconstruction and local radiation.  The development of multiple lipomas during immunotherapy is a novel association which has yet to be reported in the literature.  We discuss a putative mechanism of action of pembrolizumab-induced lipomas and describe the patient's clinical course.


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