At-Home Microneedling of Acral Skin to Increase Percutaneous Absorption of Imiquimod

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Kate Beekman
Danielle DePalo
James Grichnik
Lilia Correa
Jonathan Zager


Microneedling, acral skin, melanoma, acral lentiginous melanoma, melanoma in situ, malignant melanoma in situ, MMIS, skin cancer, imiquimod, topicals, curettage


1. Nakamura Y, Fujisawa Y. Diagnosis and Management of Acral Lentiginous Melanoma. Curr Treat Options Oncol. 2018;19(8):42. Published 2018 Jun 27. doi:10.1007/s11864-018-0560-y

2. Pandit AS, Geiger EJ, Ariyan S, Narayan D, Choi JN. Using topical imiquimod for the management of positive in situ margins after melanoma resection. Cancer Med. 2015;4(4):507-12. Epub 20150126. doi: 10.1002/cam4.402. PubMed PMID: 25620351; PubMed Central PMCID: PMC4402064.

3. Al-Mayahy MH, Sabri AH, Rutland CS, et al. Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. Eur J Pharm Biopharm. 2019;139:33-43. doi: 10.1016/j.ejpb.2019.02.006

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