Malignant Melanoma within a Giant Congenital Melanocytic Nevus in a Pediatric Patient

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Jackson Green
Jessica Nye
Kelly Turner
Matthew R Greives
Kate Mowrey
Adelaide A Herbert
Autumn Atkinson


Melanoma, Giant Congenital Melanocytic Nevus


While giant congenital melanocytic nevi are rare lesions in the pediatric population, malignant transformation within these lesions remains even more rare. A 22-month-old male patient developed a 6.5 mm Clark’s Level IV melanoma within a giant congenital nevus with an activating NRAS variant. The need for frequent surveillance and screening of giant congenital melanocytic nevi is essential to identify early signs of melanoma, even in the pediatric population.


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