Lobular Panniculitis in a Patient with Chronic Lymphoid Leukemia

Main Article Content

Melissa Cheng
Diem Pham
Gene Kim


panniculitis, panniculitis with chronic lymphoid leukemia, cutaneous manifestations of chronic lymphoid leukemia


Panniculitis is the inflammation of the subcutaneous fat that presents as red, painful nodules under the skin and may be a manifestation of internal disease. Causes of lobular panniculitis include systemic lupus erythema, pancreatic disorders, α1-antitrypsin deficiency, or infection. This case discusses a 63-year-old female that presents with lobular panniculitis without vasculitis associated with chronic lymphoid leukemia. Though cutaneous manifestations due to chronic lymphoid leukemia are not uncommon, it is rare to see panniculitis associated with chronic lymphoid leukemia.


1. Ter Poorten, M.C. and B.H. Thiers, Panniculitis. Dermatol Clin, 2002. 20(3): p. 421-33, vi.

2. Diaz Cascajo, C., S. Borghi, and W. Weyers, Panniculitis: definition of terms and diagnostic strategy. Am J Dermatopathol, 2000. 22(6): p. 530-49.

3. Requena, L. and E. Sánchez Yus, Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol, 2001. 45(3): p. 325-61; quiz 362-4.

4. Scarfò, L., A.J.M. Ferreri, and P. Ghia, Chronic lymphocytic leukaemia. Critical Reviews in Oncology/Hematology, 2016. 104: p. 169-182.

5. Plaza, J.A., et al., Unusual cutaneous manifestations of B-cell chronic lymphocytic leukemia. Journal of the American Academy of Dermatology, 2009. 60(5): p. 772-780.

6. Agnew, K.L., et al., Cutaneous findings in chronic lymphocytic leukaemia. Br J Dermatol, 2004. 150(6): p. 1129-35.

7. Szukalski, Ł., et al., Cutaneous manifestation of chronic lymphocytic leukemia: a case report and a literature review. Postepy Dermatol Alergol, 2019. 36(6): p. 778-780.

8. Fabbro, S.K., et al., Panniculitis in Patients Undergoing Treatment With the Bruton Tyrosine Kinase Inhibitor Ibrutinib for Lymphoid Leukemias. JAMA Oncology, 2015. 1(5): p. 684-686.