Successful Treatment of Multiple Post-Operative Keratoacanthomas with Topical 5-Fluorouracil
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Keywords
keratoacanthoma, 5-fluorouracil, topical 5-FU
Abstract
Keratoacanthomas (KAs) are fast-growing tumors and can be difficult to distinguish from squamous cell carcinomas (SCCs). Most KAs are sporadic, but KAs may also arise following traumatic procedures. We report the case of a 94-year-old male who developed multiple KAs following surgical excision of an SCC on the right lower extremity. The patient declined additional procedures including biopsy, surgery, or intralesional therapy. He was started on 5% topical FU using a 2 week on, 2 week off regimen for 16 weeks with resolution of disease. No recurrence was noted at 13 months. Topical 5-FU is a conservative, non-invasive treatment for post-traumatic KAs that is particularly suitable in the elderly, in whom the risks and morbidity from surgical or other non-invasive approaches are worth considering.
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Nour Kibbi, Yale University School of Medicine
Clinical Instructor
Section of Dermatologic Surgery
Yale University School of Medicine