Toluidine blue for extramammary Paget’s disease in Mohs micrographic surgery
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Keywords
Toluidine blue, extramammary Paget’s disease, Mohs micrographic surgery, histological stains
Abstract
Introduction: We report an elderly gentleman with Extramammary Paget’s disease (EMPD) treated with Mohs micrographic surgery (MMS) using Toluidine blue staining intraoperatively as to detect the Paget’s cells.
Case Presentation: An elderly man presented with an erythematous plaque on the left inguinal fold which showed in-situ EMPD on histopathological examination. Investigations for secondary EMPD were negative and the patient was treated with MMS. During MMS, the specimens from the patient were stained using Toluidine blue in order to detect the Paget cells and to determine the appropriate negative margin. At 4 years follow up the patient is free of recurrence.
Conclusion: Toluidine blue is a fast, user-friendly dye that can be used intraoperatively during MMS as to detect Paget cells and thus to determine the appropriate negative margin.
References
2. Petrie MS, Hess S, Benedetto A V. Automated 15-minute cytokeratin 7 immunostaining protocol for extramammary Paget’s disease in Mohs micrographic surgery. Dermatologic Surgery. 2011;37(12):1811-1815. doi:10.1111/j.1524-4725.2011.02181.x.
3. Kanitakis J. Mammary and extramammary Paget’s disease. Journal of the European Academy of Dermatology and Venereology. 2007;21(5):581-590. doi:10.1590/abd1806-4841.20153189
4. Hendi A, Perdikis G, Snow JL. Unifocality of extramammary Paget disease. Journal of the American Academy of Dermatology. 2008;59(5):811-813. doi:10.1016/j.jaad.2008.08.006
5. Logan ME, Zaim MT. Histologic stains in dermatopathology. Journal of the American Academy of Dermatology. 1990;22(5):820-830. doi:10.1016/S0190-9622(08)81173-5
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