Diethylene Glycol Monoethyl Ether Versus Propylene Glycol and Their Impact on Topical Clobetasol Propionate Drug Delivery

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Leon Kircik MD
Ryan Hartung PhD
Garrett Campbell
Ewa Hawkins MD PhD

Keywords

Plaque Psoriasis, Clobetasol

References

1. Osborne DW, Musakhanlan J. Skin Penetration and Permeation Properties of Transcutol - Neat or Diluted Mixtures. AAPS Pharm Sci Tech 2018;19(8):3512-3533.

2. Del Ross JQ. Topical Corticosteroid Therapy for Psoriasis - A Review of Clobetasol Propionate 0.025% Cream and the Relevance of Penetration Modification. J Clin Aesthetic Dermatol 2020;13(2):22-29.

3. Draelos ZD, Fowler JF, Cornelison R. A Randomized, Parallel Group, Open Label, Multicenter Study to Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing with Clobetasol Propionate Cream (Impoyz), 0.025% versus Clobetasol Propionate (Temovate) Cream, 0.05% in Subjects with Moderate to Severe Plaque Psoriasis. Skin 2018;2(6):410-420.