Aquagenic Wrinkling and Pain of The Fingertips: A Case Report and Review of Aquagenic Palmoplantar Keratoderma

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Imran Baig
UTHealth McGovern Medical School at Houston

Dr. Mika Tabata
University of Texas at Austin, Dell Medical Center, Department of Dermatology, Austin, TX

Dr. Anokhi Jambusaria-Pahlajani
University of Texas at Austin, Dell Medical Center, Department of Dermatology, Austin, TX

Keywords

aquagenic palmoplantar keratoderma, botulinum toxin, cystic fibrosis, palmar wrinkling, water exposure

Abstract

Aquagenic palmoplantar keratoderma (APPK) classically presents as exaggerated wrinkling of the palms after brief immersion in water that lasts 10 minutes to a few hours. We present a case report of a 19-year-old female who presented with peeling, sensitivity, and pain on her palmar hands, most prominently on her fingertips, that persists for several minutes to an hour after touching water. This case highlights a unique presentation of APPK predominantly involving the patient’s palmar fingertips, a distribution not described in the literature. Current therapies are unsatisfactory and better therapies are needed to improve the quality of life for patients with APPK.

References

1. Cabrol C, Bienvenu T, Ruaud L, et al. Aquagenic Palmoplantar Keratoderma as a CFTR-related Disorder. Acta Derm Venereol. 2016;96(6):848-849.

2. Atzori L, Ferreli C, Rongioletti F. Aquagenic (pseudo) keratoderma (aquagenic palmoplantar keratoderma, aquagenic wrinkling of palms). Clin Dermatol. 2021;39(2):256-260.

3. Yagerman SE, Lager M, Soter NA. Acquired aquagenic papulotranslucent acrokeratoderma. Dermatol Online J. 2016;22(12)

4. Gironi LC, Colombo E, Zottarelli F, et al. Aberrant expression of aquaporin-3 in hereditary papulotranslucent acrokeratoderma and aquagenic palmoplantar keratoderma. Eur J Dermatol EJD. 2018;28(2):262-263.

5. Medhus EJ, DeVore AC, DeVore K. Aquagenic palmoplantar keratoderma therapeutic response to topical glycopyrronium. JAAD Case Rep. 2021;13:17-19.

6. Sracic JK, Krishnan RS, Nunez-Gussman JK, Orengo IF, Hsu S. Hereditary papulotranslucent acrokeratoderma: a case report and literature review. Dermatol Online J. 2005;11(3):17.

7. Houle MC, Al Dhaybi R, Benohanian A. Unilateral aquagenic keratoderma treated with botulinum toxin A. J Dermatol Case Rep. 2010;4(1):1-5.

8. Diba VC, Cormack GC, Burrows NP. Botulinum toxin is helpful in aquagenic palmoplantar keratoderma. Br J Dermatol. 2005;152(2):394-395.

9. Kutlubay Z, Engin B, Baglam S, Khatib R, Demirkesen C, Aydemir EH. Case report: Treatment failure in a case of aquagenic syringeal acrokeratoderma. J Cosmet Laser Ther. 2015;17(4):224-226.

10. Dixit N, Sardana K, Tandon S, Singh Y. Atypical aquagenic keratoderma treated with oxybutynin chloride. An Bras Dermatol. 2018;93(2):308-309.

11. Errichetti E, Piccirillo A. Aquagenic keratoderma treated with tap water iontophoresis. Indian J Dermatol. 2015;60(2):212.

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Published
Sep 15, 2023
DOI https://doi.org/10.25251/skin.7.5.11

Article Details

How to Cite
Baig, I., Tabata, M., & Jambusaria-Pahlajani, A. . (2023). Aquagenic Wrinkling and Pain of The Fingertips: A Case Report and Review of Aquagenic Palmoplantar Keratoderma. SKIN The Journal of Cutaneous Medicine, 7(5), 1030–1034. https://doi.org/10.25251/skin.7.5.11
Issue
Vol. 7 No. 5 (2023): September 2023 Issue
Section
Brief Articles
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