Calcinosis Cutis: Case Report Of Topical Sodium Thiosulfate (STS) Treatment In The Context Of Dermatomyositis

Main Article Content

Rakahn Haddadin
Omeed Ahadiat

Keywords

Calcinosis cutis, topical sodium thiosulfate, sodium thiosulfate, topical treatment

Abstract

A 44-year-old woman with dermatomyositis had multiple painful calcinosis cutis lesions that were affecting her daily living. Many tests and labs were run to assess the severity and the progression of these lesions. Multiple treatment options were tried and failed before, leading to an introduction of topical sodium thiosulfate. The topical formula provided a great decrease in pain and discomfort for the patient. This led to the patient never needing injectable treatment that would have caused more pain both physically and emotionally

References

1) Le C, Bedocs PM. Calcinosis Cutis. [Updated 2019 Sep 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.

2) Callen JP. Dermatomyositis. Lancet. 2000 Jan 1;355(9197):53-7. PubMed

3) Ma, J.E., Ernste, F.C., Davis, M.D.P., and Wetter, D.A. Topical sodium thiosulfate for calcinosis cutis associated with autoimmune connective tissue diseases: the Mayo Clinic experience, 2012– 2017. Clin Exp Dermatol. 2019;

4) Reiter, N., El-Shabrawi, L., Leinweber, B., Berghold, A., and Aberer, E. Calcinosis cutis: Part II. Treatment options. (quiz 23-4)J Am Acad Dermatol. 2011;

5) Tajalli M, Qureshi AA. Successful treatment of calcinosis cutis of fingertip in the setting of CREST syndrome with topical 20% sodium thiosulfate. JAAD Case Rep. 2019;5(11):988– 990. Published 2019 Oct 28. doi:10.1016/j.jdcr.2019.08.011

6) Ratsimbazafy, V., Bahans, C., & Guigonis, V. (2012). Dramatic diminution of a large calcification treated with topical sodium thiosulfate. Arthritis & Rheumatism, 64(11), 3826-3826. doi:10.1002/art.34628

7) Jost, J., Bahans, C., Courbebaisse, M., Tran, T.-A., Linglart, A., Benistan, K., Lienhardt, A., Mutar, H., Pfender, E., Ratsimbazafy, V., & Guigonis, V. (2016). Topical sodium thiosulfate: A treatment for calcifications in hyperphosphatemic familial tumoral calcinosis? The Journal of Clinical Endocrinology & Metabolism, 101(7), 2810–2815. https://doi.org/10.1210/jc.2016-1087