Eosinophilic Annular Erythema- Successful Treatment with Dupilumab

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Alina G Zufall http://orcid.org/0000-0002-7622-2270
Rung-chi Li
Barrett J Zlotoff
Monica G Lawrence
Richard H Flowers


eosinophilic annular erythema, Dupilumab, biologic therapy, eosinophilic dermatosis


Eosinophilic annular erythema (EAE) is a rare eosinophilic dermatosis with few documented cases in the literature. It is considered either a distinct entity or subtype of Well’s syndrome (eosinophilic cellulitis), but EAE, in contrast to Well’s syndrome, is characterized by a chronic course and resistance to treatment. Therapies with reported efficacy include anti-malarial medications, suplatast tosilate, and dapsone. We report the first adult case of EAE to respond to dupilumab, an IL-4 receptor antagonist, which targets the type 2 inflammatory response associated with tissue eosinophilia. 


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