Association Between Baseline Disease Characteristics and Relapse-Free Survival in Patients With BRAF V600–Mutant Resected Stage III Melanoma Treated With Adjuvant Dabrafenib + Trametinib or Placebo

Main Article Content

Dirk Schadendorf
University Hospital Essen, Essen, and German Cancer Consortium, Heidelberg, Germany

Reinhard Dummer
University Hospital Z?rich Skin Cancer Center, Z?rich, Switzerland

Axel Hauschild
University Hospital Schleswig-Holstein, Kiel, Germany

Mario Santinami
Fondazione Istituto Nazionale Tumori, Milano, Italy

Victoria Atkinson
Princess Alexandra Hospital, Gallipoli Medical Research Foundation, University of Queensland, Woolloongabba, QLD, Australia

Mario Mandala
Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy

Vanna Chiarion-Sileni
Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy

James Larkin
The Royal Marsden NHS Foundation Trust, London, United Kingdom

Marta Nyakas
Oslo University Hospital, Oslo, Norway

Caroline Dutriaux
Centre Hospitalier Universitaire de Bordeaux, H?pital Saint-Andr?, Bordeaux, France

Andrew Haydon
The Alfred Hospital, Melbourne, VIC, Australia

Laurent Mortier
Universit? de Lille, INSERM U 1189, CHRU Lille, Lille, France

Caroline Robert
Gustave Roussy and Paris-Sud-Paris-Saclay University, Villejuif, France

Jacob Schachter
Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Christine-Elke Ortmann
Novartis Pharma AG, Basel, Switzerland

Egbert de Jong
Novartis Pharma AG, Basel, Switzerland

Edward Gasal
Novartis Pharmaceuticals Corporation, East Hanover, NJ

Richard Kefford
Macquarie University, Melanoma Institute Australia, Westmead Hospital, and The University of Sydney, Sydney, NSW, Australia

John M Kirkwood
Melanoma Program, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA

Georgina V Long
Melanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, NSW, Australia

Keywords

melanoma, BRAF V600, dabrafenib, trametinib

Abstract

Abstract not available.

References

1. Hauschild A, et al. J Clin Oncol. 2018;36:3441-3449.

2. Long GV, et al. N Engl J Med. 2017;377:1813-1823.

3. Tafinlar (dabrafenib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2018.

4. Mekinist (trametinib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2018.

5. Tafinlar (dabrafenib) [summary of product characteristics]. Camberley, UK: Novartis Pharmaceuticals UK Ltd; 2018.
https://www.ema.europa.eu/en/documents/product-information/tafinlar-epar-product-information_en.pdf. Accessed April 18, 2019.

6. Mekinist (trametinib) [summary of product characteristics]. Camberley, UK: Novartis Pharmaceuticals UK Ltd; 2019.
https://www.ema.europa.eu/en/documents/product-information/mekinist-epar-product-information_en.pdf. Accessed April 18, 2019.

7. Dummer R, et al. ESMO 2018 [poster 1250P].

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Poster PDF
Published
Nov 9, 2019
DOI https://doi.org/10.25251/skin.3.supp.53

Article Details

How to Cite
Schadendorf, D., Dummer, R., Hauschild, A., Santinami, M., Atkinson, V., Mandala, M., Chiarion-Sileni, V., Larkin, J., Nyakas, M., Dutriaux, C., Haydon, A., Mortier, L., Robert, C., Schachter, J., Ortmann, C.-E., de Jong, E., Gasal, E., Kefford, R., Kirkwood, J. M., & Long, G. V. (2019). Association Between Baseline Disease Characteristics and Relapse-Free Survival in Patients With BRAF V600–Mutant Resected Stage III Melanoma Treated With Adjuvant Dabrafenib + Trametinib or Placebo. SKIN The Journal of Cutaneous Medicine, 3, S53. https://doi.org/10.25251/skin.3.supp.53
Issue
Vol. 3 (2019): Supplemental Issue: Scientific Posters Presented at 2019 Fall Clinical Dermatology Conference®-Las Vegas
Section
Skin Cancer
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