Transitioning Between Biologics
Background: Transitioning between biologics has become an important part of practice.
Objective: Patients with moderate to severe plaque psoriasis who are on biologics can have efficacy failures, as well as safety concerns. This would often necessitate a change of biologic, which may be within the same class or to a different class. A change due to an adverse event from the presently used biologic may resolve or require treatment until a new biologic is introduced, which may pose some delay in the initiation of the subsequent biologic.
Methods: A review of the literature and guidelines published were performed.
Results: A practical guide to transitioning between biologics are presented
Limitations: There are no randomized placebo-controlled trials to determine the best method of transitioning between biologics.
Conclusion: Transitioning between biologics is an option for those patients requiring such a change either for safety or efficacy reasons.
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