Ampicillin use in Acne
Introduction: In one author’s experience, ampicillin is an effective alternative antibiotic for acne; however, current literature for ampicillin use in acne is scant. The objective of this study was to demonstrate the response of oral Ampicillin in acne.
Methods: A retrospective analysis of 243 patients with Acne vulgaris treated with Ampicillin 500mg twice daily was conducted. The severity of acne (on a scale of 0 to 3) at the last visit was compared with baseline severity determined at the initial visit. Results were analyzed using the paired samples t-test.
Results: The average severity of acne was reduced from 1.54 to 0.90 (p < 0.001). The average severity was reduced from 1.69 to 1.09 (p < 0.001) among men, and from 1.48 to 0.84 (p < 0.001) among woman. Lastly, average severity was decreased from 1.67 to 1.12 (p < 0.001) in patients with nodulocystic acne, from 1.45 to 0.77 (p < 0.001) with inflammatory acne patients, and from 1.00 to 0.38 (p < 0.001) in patients with comedonal acne.
Limitations: This study was limited by its retrospective nature and analysis of a small patient population. Additionally, a validated acne scoring system was not used due to provider documentation.
Conclusion: To conclude, Ampicillin had a positive effect on our patient’s acne.
Farrah G , Tan E. The use of oral antibiotics in treating acne vulgaris: a new approach. Dermatol Ther 2016;29:377-84.
Guzman AK, Choi JK , James WD. Safety and effectiveness of amoxicillin in the treatment of inflammatory acne. Int J Womens Dermatol 2018;4:174-5.
Shore RN. Usefulness of ampicillin in treatment of acne vulgaris. J Am Acad Dermatol 1983;9:604-5.
Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 2016;74:945-73.e33.
Abstract - 1322 Full Article PDF - 76
- There are currently no refbacks.