Electrical Impedance Spectroscopy Versus Clinical Inspection Approaches: Melanoma Efficacy Detection Comparison

Main Article Content

Ryan M Svoboda
Abigail I Franco
Darrell S Rigel

Keywords

melanoma, detection, electrical impedance spectroscopy

Abstract

Early detection of melanoma continues to provide a diagnostic challenge for Dermatologists and other healthcare providers. Recently, there has been increased interest in the use of novel technology to aid in the detection of melanoma. We retrospectively compared the results of one such technology—electrical impedance spectroscopy (EIS)—to existing melanoma detection tools in 265 cases of malignant melanoma. Lesions were analyzed using EIS, the clinical ABCD rule, the ABCD dermoscopy rule, and the standard and weighted melanoma 7-point checklists. The proportion of false negative cases was calculated for each method. Overall, EIS produced a lower false negative rate (3.4%) than the clinical ABCD rule, ABCD dermoscopy, the 7-point checklist, and the weighted 7-point checklist (12.8%, 45.8%, 50.8%, and 39.3%, respectively). Additionally, there was a statistically significant, moderate correlation between EIS score and tumor staging (Spearman rho=0.32, p<0.001). In this sample, EIS was very sensitive for the detection of melanoma and may prove to be a useful clinical adjunct for ruling out malignant melanoma in challenging cases.

References

1. Glazer AM, Rigel DS, Winkelmann RR, Farberg AS. Clinical Diagnosis of Skin Cancer: Enhancing Inspection and Early Recognition. Dermatologic clinics 2017;35:409-16.

2. Cancer Facts and Figures 2017. 2017. (Accessed September 13, 2017, at http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-048738.pdf.)

3. Winkelmann RR, Farberg AS, Glazer AM, et al. Integrating Skin Cancer-Related Technologies into Clinical Practice. Dermatologic clinics 2017;35:565-76.

4. Malvehy J, Hauschild A, Curiel-Lewandrowski C, et al. Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multicentre, prospective and blinded clinical trial on efficacy and safety. The British journal of dermatology 2014;171:1099-107.

5. Braun RP, Mangana J, Goldinger S, French L, Dummer R, Marghoob AA. Electrical Impedance Spectroscopy in Skin Cancer Diagnosis. Dermatologic clinics 2017;35:489-93.

6. Friedman RJ, Gutkowicz-Krusin D, Farber MJ, et al. The diagnostic performance of expert dermoscopists vs a computer-vision system on small-diameter melanomas. Archives of dermatology 2008;144:476-82.

7. Witheiler DD, Cockerell CJ. Sensitivity of diagnosis of malignant melanoma: a clinicopathologic study with a critical assessment of biopsy techniques. Experimental dermatology 1992;1:170-5.

8. Grin CM, Kopf AW, Welkovich B, Bart RS, Levenstein MJ. Accuracy in the clinical diagnosis of malignant melanoma. Archives of dermatology 1990;126:763-6.