Electrical Impedance Spectroscopy Versus Clinical Inspection Approaches: Melanoma Efficacy Detection Comparison

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Ryan M Svoboda
Abigail I Franco
Darrell S Rigel


melanoma, detection, electrical impedance spectroscopy


Early detection of melanoma continues to provide a diagnostic challenge for Dermatologists and other healthcare providers. Recently, there has been increased interest in the use of novel technology to aid in the detection of melanoma. We retrospectively compared the results of one such technology—electrical impedance spectroscopy (EIS)—to existing melanoma detection tools in 265 cases of malignant melanoma. Lesions were analyzed using EIS, the clinical ABCD rule, the ABCD dermoscopy rule, and the standard and weighted melanoma 7-point checklists. The proportion of false negative cases was calculated for each method. Overall, EIS produced a lower false negative rate (3.4%) than the clinical ABCD rule, ABCD dermoscopy, the 7-point checklist, and the weighted 7-point checklist (12.8%, 45.8%, 50.8%, and 39.3%, respectively). Additionally, there was a statistically significant, moderate correlation between EIS score and tumor staging (Spearman rho=0.32, p<0.001). In this sample, EIS was very sensitive for the detection of melanoma and may prove to be a useful clinical adjunct for ruling out malignant melanoma in challenging cases.


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