61-Year-Old White Female with a Non-Healing Ulcerated Ankle Mass
Merkel cell carcinoma is a rare cutaneous carcinoma from the tactile Merkel cells. With fewer than half the patients surviving more than one year and fewer than 20% surviving beyond five years. These tumors are rarely suspected until the biopsy results return. Polyoma virus is associated with up to 80% of the tumors. 53% present on the head and neck and 35% present on the extremities while larger lesions are exceedingly rare in either location. Recently, A newly approved drug, Avelumab, has shown tumor response in patients with some patients experiencing complete remission.
Toker C. Trabecular carcinoma of the skin. Arch of Dermatol 1972; 105:107 – 110.
Han S, North J, Canavan T, et al. Merkel cell carcinoma. Hematol Oncol Clin N Amer. 2012; 26:1351 – 1374
Goessling, W, Mckee P, Mayer R. Merkel cell carcinoma. J Clin Oncol. 2002; 20:588 – 598.
Oram C , Bartus C S, Purcell S. Merkel cell carcinoma: A review. Cutis. 2016 Volume 97, 4 to 90 – 295
Wang T, Byrne, P, Et al, Semin Cutan Med Surg. 2011 Mar:30 (1) 48-56
Lemos B, Storer B, Lyer J, et al. Pathologic nodal evaluation approves prognostic accuracy and Merkel cell carcinoma; J Amer Acad Derm. 2010; 63(5): 751 – 761.
Bobos M, Hytiroglou P, Kostopoulos I, et al. immunohistochemical distinction between Merkel cell carcinoma and small cell carcinoma of the lung. Dermatopathol. 2006; 28:99 – 104.
Pearson, J , Meyers, A Skin cancer – Merkel cell carcinoma, Medscape updated March 27, 2017
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