Subcorneal Pustular Dermatosis Successfully Treated with Acitretin in a Patient with Glucose-6-Phoshate Dehydrogenase Deficiency
Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis. SPD most commonly presents as a serpiginous pattern of pustules on the trunk or intertriginous areas of middle-aged females. It tends to have a chronic disease course and patients may experience relapses. Dapsone currently remains the treatment of choice for SPD. However, in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, alternative therapies are required. We report a case of subcorneal pustular dermatosis in a G6PD deficient patient successfully treated with acitretin.
Cohen PR. Sweet's syndrome - a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis. 2007;2:34.
Canpolat F, Akpinar H, Cemil BC, Eskioglu F, Ozturk E. A case of subcorneal pustular dermatosis in association with monoclonal IgA gammopathy successfully treated with acitretin. J Dermatolog Treat 2010; 21: 114-6.
Marlière V, Beylot-Barry M, Beylot C, Doutre M. Successful treatment of subcorneal pustular dermatosis (Sneddon–Wilkinson disease) by acitretin: Report of a case. Dermatology. 1999;199:153–155.
Teixeira M, Alves R, Selores M. Subcorneal pustular dermatosis in association with a monoclonal ıgA gammopathy: Successful treatment with acitretin. Eur J Dermatol. 2006;16:588–590.
James, W. D., Elston, D. M., Berger, T. G., & Andrews, G. C. Seborrheic Dermatitis, Psoriasis, Recalcitrant Palmoplantar Eruptions, Pustular Dermatitis, and Erythroderma in Andrews' Diseases of the skin: Clinical dermatology. 2011;10(3)185-198.
Luzzatto L., Nannelli C. & Notaro R. Glucose-6-Phosphate Dehydrogenase Deficiency. Hematol Oncol Clin N. 2016;30:373–93.
Abstract - 120 PDF - 28
- There are currently no refbacks.