Subcorneal Pustular Dermatosis Successfully Treated with Acitretin in a Patient with Glucose-6-Phoshate Dehydrogenase Deficiency

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Mojgan Hosseinipour
Dana Marie Baigrie
Jonathan Crane


subcornal pustular dermatosis, Sneddon Wilkinson


Subcorneal pustular dermatosis (SPD) is a rare neutrophilic dermatosis. SPD most commonly presents as a serpiginous pattern of pustules on the trunk or intertriginous areas of middle-aged females. It tends to have a chronic disease course and patients may experience relapses. Dapsone currently remains the treatment of choice for SPD. However, in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, alternative therapies are required. We report a case of subcorneal pustular dermatosis in a G6PD deficient patient successfully treated with acitretin. 


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