Sixteen Years of a Pruritic Unilateral Axillary Eruption: A Rare Presentation of Extramammary Paget’s Disease

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Amy R Weiss
Robbie B Drossner
Mark Jacobson


Extramammary Paget's Disease


Extramammary Paget’s Disease (EMPD) is a rare intraepithelial adenocarcinoma of apocrine gland-bearing skin. The most common sites affected are the vulva in women and the perinanal, scrotal, and penile regions in men. One quarter of cases are extensions of an underlying visceral malignancy, usually colorectal or urothelial carcinoma. The typical presentation is an expanding erythematous plaque that shows large cells with vacuolated cytoplasm and centrally located nuclei on histology. Here we present a case of axillary EMPD that was incorrectly diagnosed and treated as various forms of dermatitis for over fifteen years. Fewer than fifteen cases of axillary EMPD have been reported in the literature in the past ten years.  


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