A Case of Refractory Cutaneous Sarcoidosis Successfully Treated with Infliximab

Main Article Content

Roudha Jassim Al-Dehneem


Refractory cutaneous sarcoidosis, infliximab, hair regrowth


Sarcoidosis is an inflammatory granulomatous disease affecting multiple organs with cutaneous sarcoidosis occurring in 25% of patients. There are several treatment options available, but alternative therapies should be considered in patients with refractory disease to standard intervention. Though they are not been FDA-approved for sarcoidosis, TNF-a inhibitors have demonstrated significant therapeutic intervention targeting proinflammatory cytokines involves in pathogenesis of sarcoidosis.  Herein, we present a case of refractory cutaneous sarcoidosis successfully treated with infliximab therapy with significant hair regrowth on the scalp.


1. Heffernan MP, Anadkat MJ. Recalcitrant cutaneous sarcoidosis responding to infliximab. Arch Dermatol. 2005;141(7):910-911. doi:10.1001/archderm.141.7.910.

2. Wanat, K.A. and Rosenbach, M., 2015. Cutaneous sarcoidosis. Clinics in chest medicine, 36(4), pp.685-702.

3. Noor, A. and Knox, K.S., 2007. Immunopathogenesis of sarcoidosis. Clinics in dermatology, 25(3), pp.250-258.

4. Saleh S, Ghodsian S, Yakimova V, Henderson J, Sharma OP. Effectiveness of infliximab in treating selected patients with sarcoidosis. Respir Med. 2006;100(11):2053-2059. doi:10.1016/j.rmed.2006.02.017.

5. Roberts SD, Wilkes DS, Burgett RA, Knox KS. Refractory sarcoidosis responding to infliximab. Chest. 2003;124(5):2028-2031. doi:10.1378/chest.124.5.2028.

6. Udkoff, J. and Cohen, P.R., 2016. Severe infliximab-induced alopecia and scalp psoriasis in a woman with Crohn’s disease: dramatic improvement after drug discontinuation and treatment with adjuvant systemic and topical therapies. Dermatology and Therapy, 6, pp.689-695.

7. Lindsey, S.F. and Tosti, A., 2013. Hair loss induced by tumor necrosis factor alpha inhibitors. J Clin Investigat Dermatol, 1(1), p.6.

8. Philpott, M.P., Sanders, D.A., Bowen, J. and Kealey, T., 1996. Effects of interleukins, colony‐stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin‐1 and tumour necrosis factor‐α in alopecia areata. British journal of dermatology, 135(6), pp.942-948.

Similar Articles

You may also start an advanced similarity search for this article.