Angiokeratoma Corporis Diffusum in the Absence of Known Metabolic Disease and Systemic Features

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Sokhna Seck
Taylor A. Bullock
Shilpi Khetarpal


Angiokeratoma corporis diffusum, Angiokeratomas, Fabry disease, α-galactosidase A


Angiokeratomas are benign capillary ectasias in the superficial dermis. Angiokeratoma corporis diffusum (ACD) is a clinical variant typically associated with an enzyme deficiency in the metabolism of glycoproteins, most notably Fabry disease. ACD has also been found to occur in a benign form with the absence of metabolic disease and lack of systemic features. We present the case of ACD in a 20-year-old male with normal enzyme function and in the absence of any detectable metabolic disorders.


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