Evolving Pink Papule in a Young Female

Main Article Content

Dr. Rachel Tannenbaum
Dr. Bernice Yan
Dr. Pooja Shah

Keywords

Porocarcinoma, Eccrine, EPC, Pink papule

Abstract

Eccrine porocarcinoma (EPC) is a rare cutaneous adnexal tumor derived from sweat glands. Typically, EPC presents as a nonspecific erythematous papule or nodule most commonly on the head, neck, or lower extremities of females in the sixth or seventh decade of life. This tumor may arise from an existing benign eccrine poroma or occur de novo. Herein, we report a case of a growing erythematous nodule with overlying telangiectasia on the lower extremity of a woman in her twenties. Biopsy revealed a cyst-like lesion beneath the epidermis comprised of clear fluid material. Both solid and cystic components were present alongside pleomorphic tumor cell aggregates characterized by mitotic figures, hyperchromasia, and necrosis. The combination of clinical presentation and the presence of ductal structures on histopathologic analysis led to a diagnosis of EPC. This case reinforces the critical importance of histopathologic analysis of a nonspecific lesion that has evolved over time and may resemble other forms of cutaneous malignancy. 

References

1. Uchiyama J, Jardim MML, Valente NYS, Camargo MFVC. The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. An Bras Dermatol. 2019 Mar-Apr;94(2):230-232. doi: 10.1590/abd1806-4841.20197280. Epub 2019 May 9. 

2. Salih AM, Kakamad FH, Baba HO, et al. Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg (Lond). 2017 Jun 20;20:74-79. Doi: 10.1016/j.amsu.2017.06.027. eCollection 2017 Aug. 

3. Alves JVP, Matos DM, Barreiros HF, Bartolo EAFLF. Variants of dermatofibroma – a histopathological study. An Bras Dermatol. May-Jun 2014;89(3):472-477. Doi: 10.1590/abd1806-4841.20142629. 

4. Gong HZ, Zheng HY, Li J. Amelanotic melanoma. Melanoma Res. 2019 Jun;29(3):221-230. Doi: 10.1097/CMR.0000000000000571. 

5. Cameron MC, Lee E, Hibler BP, et al. Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations [published correction appears in J Am Acad Dermatol. 2021 Aug;85(2):535]. J Am Acad Dermatol. 2019;80(2):303-317. doi:10.1016/j.jaad.2018.03.060

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