Eosinophilic Annular Erythema of Childhood: A Rare Case

Main Article Content

Mariana Perez
Benjamin Witkoff
Moises Lutwak
Michael Cohn
Eduardo Weiss

Keywords

Annular, erythema, eosinophilic

Abstract

Eosinophilic annular erythema (EAE) of childhood is a rare and recurrent skin condition, with only a few cases described in the literature. The etiology of EAE in children remains unclear. Clinical presentation shows a persistent, non-pruritic, urticarial annular lesions that enlarge in a centrifugal pattern. Biopsy is required for diagnosis which characteristically shows a perivascular eosinophilic infiltrate concentrated in the dermis. Although there is considerable overlap between EAE and Annular Erythema of Infancy (AEI), some proposed differences include age of onset, duration of lesions, presence of mucin deposition of histopathology, and time to resolution. This case report describes a rare case of EAE of childhood in a newborn with associated neonatal eosinophilic pustulosis and laboratory abnormalities.

References

1. Sempau L, Larralde M, Luna PC, Casas J, Staiger H. Eosinophilic annular erythema. Dermatol Online J. 2012;18(3):8.

2. Thomas L, Fatah S, Nagarajan S, Natarajan S. Eosinophilic annular erythema: successful response to ultraviolet B therapy. Clinical and Experimental Dermatology. 2015;40(8):883-886.

3. Gordon SC, Robinson SN, Abudu M, et al. Eosinophilic annular erythema treated with dupilumab. Pediatric Dermatology. 2018;35(4):e255-e256.

4. Rajput C, Nikam B, Hatkar N. Eosinophilic annular erythema in childhood: A distinct entity. Indian Journal of Paediatric Dermatology. 2021;22(3):250-253.

5. Toledo-Alberola F, Betlloch-Mas I. [Annular erythema of infancy]. Actas Dermosifiliogr. 2010;101(6):473-484.

6. Palit A, Inamadar AC. Annular, erythematous skin lesions in a neonate. Indian Dermatol Online J. 2012;3(1):45-47.

7. Hebert AA, Esterly NB. Annular erythema of infancy. Journal of the American Academy of Dermatology. 1986;14(2, Part 2):339-343.

8. Stachowitz S, Abeck D, Schmidt T, Ring J. Persistent annular erythema of infancy associated with intestinal Candida colonization. Clinical and Experimental Dermatology. 2000;25(5):404-405.

9. Hernández-Martín Á, Nuño-González A, Colmenero I, Torrelo A. Eosinophilic pustular folliculitis of infancy: A series of 15 cases and review of the literature. Journal of the American Academy of Dermatology. 2013;68(1):150-155.

10. Ladrigan MK, LeBoit PE, Frieden IJ. Neonatal Eosinophilic Pustulosis in a 2-Month Old. Pediatric Dermatology. 2008;25(1):52-55.