Weekly Isotretinoin Therapy (WIT) Study: A Potential Alternative for the Treatment of Moderate Acne Vulgaris

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Samantha Karlin
Alexandra Ritter
Courtney Linkous
Katherine Wehlage
Lara Wine Lee https://orcid.org/0000-0001-6739-4508


Acne, Isotretinoin, Moderate acne, Weekly isotretinoin


Background: Treatment options for moderate acne remain limited.

Methods: We evaluated the efficacy of once-weekly dosed isotretinoin for moderate acne. Nineteen participants took isotretinoin dosed at 1-1.5 mg/kg/week for four months. Patient clinical improvement, quality of life, and adverse effects were measured at baseline and at monthly follow-up visits. Laboratory monitoring was performed at baseline and after two months.

Results: Ninety-five percent of patients (18/19) had improvement in their acne. The majority (68%) went from a baseline of moderate acne (score 3) to either clear (score 0) or almost clear (score 1) by the end of four months. There were no major lab abnormalities or adverse events. Eighty-nine percent of patients (17/19) reported improvement in their quality of life.

Conclusion: Once weekly isotretinoin may be an additional treatment option for patients with moderate acne.


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