Diffuse Large B-cell Lymphoma in Bilateral Lower Extremities

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Leon Kou
Kevyn Niu
Austin Wong
Aaron Chen
Sid Danesh


Lymphoma, B cell, diffuse large b cell, cancer


Diffuse large B-cell lymphoma, leg type, is a rare variant of primary cutaneous B-cell lymphomas.  It typically presents as rapidly enlarging solitary or multiple violaceous nodules on the lower extremities.  Even with adequate treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, recurrence and systemic spread is common.  Timely treatment is necessary as this malignancy is associated with a more aggressive course than other variants of primary cutaneous B-cell lymphomas and overall prognosis is poor.


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