Main Article Content
eccrine poromatosis, poroma, lymphoma therapy
Eccrine poromas are benign tumors that arise from the eccrine sweat ducts, commonly presenting as solitary lesions. Eccrine poromatosis, the sudden eruption of multiple eccrine poromas, is a rare phenomenon that generally occurs in immunosuppressed patients at any time after receiving treatment for malignancy. We report a case of eccrine poromatosis in a 79-year-old male patient with a previous history of recurrent T-cell lymphoma. Over the course of his disease, he was treated with polychemotherapy, radiation, and a definitive bone marrow transplant. The patient presented to the dermatology clinic 18 years after his initial diagnosis with a new onset of pruritic papules on the neck and chest. Histologic evaluation revealed all lesions to be eccrine poromas. This is the longest reported time interval between initial diagnosis of a primary malignancy and development of eccrine poromatosis. There is no evidence at this time to suggest that appearance of such lesions is indicative of cancer recurrence; therefore, there is no indication for further oncologic evaluation.
2. Sawaya JL, Khachemoune A. Poroma: a review of eccrine, apocrine, and malignant forms. Int J Dermatol. 2014;53(9):1053-1061.
3. Kurokawa M, Amano M, Miyaguni H, et al. Eccrine poromas in a patient with mycosis fungoides treated with electron beam therapy. Brit J Dermatol. 2001;145(5):830-833.
4. Mahlberg MJ, Mcginnis KS, Draft KS, Fakharzadeh SS. Multiple eccrine poromas in the setting of total body irradiation and immunosuppression. J Am Acad Dermatol. 2006;55(2):S46-S49.
5. Navi, D., Fung, M., & Lynch, P. J. Poromatosis: the occurrence of multiple eccrine poromas. Dermatol Online J. 2008;14(1).
6. Sherman V, Reed J, Hollywood K, et al. Poromas and porokeratosis in a patient treated for solid-organ and haematological malignancies. Clin Exp Dermatol. 2009;35:e130-e132.
7. Diamantis ML, Richmond HM, Rady PL, et al. Detection of Human Papillomavirus in Multiple Eccrine Poromas in a Patient With Chronic Graft-vs-Host Disease and Immunosuppression. Arch Dermatol. 2010;147(1):120-122.
8. Fujii K, Aochi S, Takeshima C, et al. Eccrine Poromatosis Associated with Polychemotherapy. Acta Derm Venereol. 2012;92(6):687-690.
9. Nguyen BT, Lortscher, DN, & Lee RA. Multiple poromas in a bone marrow transplant recipient: A case report. Dermatol Online J. 2012;18(7).
10. Miura T, Yamamoto T. Eruptive poromatosis following radiotherapy. Am J Dermatopathol. 2013;35:615-617.
11. Garshick M, DeFilippis EM, Harp J, et al. Eccrine poromatosis in a patient with acute myeloid leukemia following chemotherapy. Dermatol Online J. 2014;20(11).
12. Deckelbaum S, Touloei K, Shitabata PK, Sire DJ, Horowitz D. Eccrine poromatosis: case report and review of the literature. Int J Dermatol. 2013;53(5):543-548.
13. Mayo TT, Kole L, Elewski B. Eccrine Poromatosis: Case Report, Review of the Literature, and Treatment. Skin Appendage Disord. 2015;1(2):95-98.
14. Takahashi C, Nishi K, Minami-Hori M, et al. Multiple poromas following combination chemotherapy and autologous peripheral blood stem cell transplantation. J Dermatol. 2015;42:430-432.
15. Aung PP, Rady PL, Nagarajan P, et al. Detection of Merkel Cell Polyoma Virus and Beta Human Papillomavirus in Multiple Eccrine Poromas in a Patient with Acute Leukemia Treated with Stem Cell Transplant. Am J Dermatopathol. 2017;39(6):489-491.
16. Lim TM, Weir J, Fearfield L. Eruptive poromatosis in a patient with breast cancer. J Cutan Pathol. 2018;45:708-710.
17. Valdebran MA, Hong C, Cha J. Multiple eruptive eccrine poromas associated with chemotherapy and autologous bone marrow transplantation. Indian Dermatol Online J. 2018;9:259-261.
18. Nguyen K, Kim, G, & Chiu, M. Eccrine poromatosis following chemotherapy and radiation therapy. Dermatol Online J. 2019; 25(11).
19. Marsh RL, Kaffenberger B, Pootrakul L, et al. Multiple Plantar Poromas in a Stem Cell Transplant Patient. Cureus. 2020;12(6): e8773.
20. Ullah K, Pichler E, Fritsch P. Multiple eccrine poromas arising in chronic radiation dermatitis. Acta Derm Venereol. 1989;69(1):70.
21. North JP, Lo J, Landers M. Poromatosis in pregnancy: a case of 8 eruptive poromas in the third trimester. Cutis. 2012;89(2): 81-83.
22. Goldner R. Eccrine Poromatosis. Arch Dermatol. 1970;101(5):606-608.
23. Ogino A. Linear Eccrine Poroma. Arch Dermatol. 1976; 112(6):841-844.
24. Yoshii Y, Matsuo S, Nishizawa A, Satoh T. Multiple eccrine poromas in a patient with systemic lupus erythematosus. Eur J Dermatol. 2018 Dec 1;28(6):837.
25. Wilkinson RD, Schopflocher P, Rozenfeld M. Hidrotic Ectodermal Dysplasia With Diffuse Eccrine Poromatosis. Arch Dermatol. 1977;113(4):472–476.
26. Whitley DB, Mansell JEKL. Multiple eccrine poromas in the paw of a dog. Veterinary Dermatology. 2011;23(2):167-e34.
27. Nishioka M, Kunisada M, Fujiwara N, Oka M, Funasaka Y, Nishigori C. Multiple apocrine poromas: a new case report. J Cutan Pathol. 2015 Nov;42(11):894-896.
28. Hashizume S, Ansai S, Matsuoka Y, Omi T, Kawana S. Case of multiple apocrine poroma in a patient without receiving radiation or chemotherapy. J Dermatol. 2014 Feb;41(2):174-175.