Characteristics of Patients With a Complete Response Treated With Dabrafenib + Trametinib Combination Therapy: Findings From Pooled COMBI-d and COMBI-v 5-Year Analysis

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Caroline Robert
Gustave Roussy and Paris-Sud-Paris-Saclay University, Villejuif, France

Jean Grob
Aix-Marseille University, Marseille, France

Daniil Stroyakovskiy
Moscow City Oncology Hospital, Moscow, Russia

Boguslawa Karaszewska
Przychodnia Lekarska KOMED, Konin, Poland

Axel Hauschild
University Hospital Schleswig-Holstein, Kiel, Germany

Evgeny Levchenko
6Petrov Research Institute of Oncology, St Petersburg, Russia

Vanna Sileni
Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy

Jacob Schachter
Ella Lemelbaum Institute for Immuno-Oncology and Melanoma, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Claus Garbe
Department of Dermatology, University of T?bingen, T?bingen, Germany

Igor Bondarenko
Dnipropetrovsk State Medical Academy, Dnipropetrovsk, Ukraine

Paul Nathan
Mount Vernon Cancer Centre, Northwood, UK

Antoni Ribas
University of California, Los Angeles, CA

Michael Davies
The University of Texas MD Anderson Cancer Center, Houston, TX

Keith Flaherty
Dana-Farber Cancer Institute/Harvard Medical School and Massachusetts General Hospital, Boston, MA

Paul Burgess
Novartis Pharma AG, Basel, Switzerland

Monique Tan
Novartis Pharmaceuticals Corporation, East Hanover, NJ

Eduard Gasal
Novartis Pharmaceuticals Corporation, East Hanover, NJ

Dirk Schadendorf
University Hospital Essen, Essen, and German Cancer Consortium, Heidelberg, Germany

Georgina Long
Melanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, NSW, Australia

Keywords

Melanoma, BRAF, Patient Characteristics

Abstract

Abstract not available.

References

1. Tafinlar (dabrafenib) [package insert]. East Hanover, NJ: Novartis PharmaceuticalsCorporation; 2020.

2. Mekinist (trametinib) [package insert]. East Hanover, NJ: Novartis PharmaceuticalsCorporation; 2020.

3. Tafinlar (dabrafenib) [summary of product characteristics]. Camberley, UK: NovartisPharmaceuticals UK Ltd; 2020. https://www.ema.europa.eu/en/documents/product-information/tafinlar-epar-product-information_en.pdf. Accessed July 31, 2020.

4. Mekinist (trametinib) [summary of product characteristics]. Camberley, UK: NovartisPharmaceuticals UK Ltd; 2020. https://www.ema.europa.eu/en/documents/product-information/mekinist-epar-product-information_en.pdf. Accessed July 31, 2020.

5. Robert C, et al. N Engl J Med. 2019;381:626-636.

6. Nathan P, et al. J Clin Oncol. 2019;37:abstract 9507.

7. Long GV, et al. Lancet Oncol. 2016;17:1743-1754.

8. Osgood C, et al. J Clin Oncol. 2019;37:abstract 9508.

9. McCoach CE, et al. Ann Oncol. 2017;28:2707-2714.

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Published
Oct 27, 2020
DOI https://doi.org/10.25251/skin.4.supp.112

Article Details

How to Cite
Robert, C., Grob, J., Stroyakovskiy, D., Karaszewska, B., Hauschild, A., Levchenko, E., Sileni, V., Schachter, J., Garbe, C., Bondarenko, I., Nathan, P., Ribas, A., Davies, M., Flaherty, K., Burgess, P., Tan, M., Gasal, E., Schadendorf, D., & Long, G. (2020). Characteristics of Patients With a Complete Response Treated With Dabrafenib + Trametinib Combination Therapy: Findings From Pooled COMBI-d and COMBI-v 5-Year Analysis. SKIN The Journal of Cutaneous Medicine, 4(6), s112. https://doi.org/10.25251/skin.4.supp.112
Issue
Vol. 4 No. 6 (2020): November Issue & Poster Presentations (FC20 Dermatology Conference®)
Section
Dermatopharmacology
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